Sorting Nexins in Protein Homeostasis
نویسندگان
چکیده
منابع مشابه
Sorting nexins
Aren’t PX domains phosphoinositide-binding motifs? Exactly! PX domains are lipid-binding modules that aid the association of their host protein with membranes enriched in specific phosphoinositides. In many cases, PX domains have been shown to bind phosphatidylinositol 3-monophosphate (PtdIns3P), a phosphoinositide enriched on the cytosolic face of endosomes. This lipid has a regulatory functio...
متن کاملThe Retromer Complex and Sorting Nexins in Neurodegenerative Diseases
The retromer complex and associated sorting nexins (SNXs) comprise a critical trafficking machinery which mediates endosomal protein sorting. Retromer and/or SNX dysfunction has been linked to several neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), and Down’s syndrome (DS). In AD, deficiency of the retromer complex or its cargo proteins impairs endosomal...
متن کاملAnalyses of sorting nexins reveal distinct retromer-subcomplex functions in development and protein sorting in Arabidopsis thaliana.
Sorting nexins (SNXs) are conserved eukaryotic proteins that associate with three types of vacuolar protein sorting (VPS) proteins to form the retromer complex. How SNXs act in this complex and whether they might work independently of the retromer remains elusive. Here, we show by genetic and cell imaging approaches that the Arabidopsis thaliana SNX1 protein recruits SNX2 at the endosomal membr...
متن کاملThree sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling
Apoptotic cells are swiftly engulfed by phagocytes and degraded inside phagosomes. Phagosome maturation requires phosphatidylinositol 3-phosphate [PtdIns(3)P], yet how PtdIns(3)P triggers phagosome maturation remains largely unknown. Through a genomewide PtdIns(3)P effector screen in the nematode Caenorhabditis elegans , we identified LST-4/SNX9, SNX-1, and SNX-6, three BAR domain-containing so...
متن کاملGenetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice.
Sorting nexins 1 (Snx1) and 2 (Snx2) are homologues of the yeast gene VPS5 that is required for proper endosome-to-Golgi trafficking. The prevailing thought is that Vps5p is a component of a retrograde trafficking complex called the retromer. Genetic and biochemical evidence suggest mammals may have similar complexes, but their biological role is unknown. Furthermore, if SNX1 and SNX2 belong to...
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ژورنال
عنوان ژورنال: Cells
سال: 2020
ISSN: 2073-4409
DOI: 10.3390/cells10010017